Temesta (Lorazepam): what you need to know about this medication for anxiety

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What is the medicine Temesta?

Témesta® is a prescribed medication for anxiety that belongs to the benzodiazepine family. Benzodiazepines (such as Xanax®, Valium® or even Tranxene®) have anxiolytic, hypnotic, muscle relaxant and anticonvulsant properties.

Attention ! Anxiety drugs (such as benzodiazepines, which are therefore prescribed for anxiety) and antidepressant drugs (which, as the name suggests, are prescribed for depression) should not be confused.

Témesta: how does it work? The active principle of the drug Témesta® is lorazepam: this anxiolytic molecule acts in the brain, at the level of type A GABA receptors (R-GABAA). It thus promotes the action of the neurotransmitter GABA, whose role is to reduce anxiety by reducing the nervous activity of neurons.

In pharmacies, the drug Témesta® exists in two forms:

  • Temesta 1 mg®: box of 30 white scored tablets,
  • Temesta 2.5 mg®: box of 30 yellow scored tablets.

To know. The drug Témesta® is not over the counter in pharmacies: it can only be obtained with a medical prescription. It is reimbursed up to 65% by the Health Insurance. Its generic is Lorazepam®.

Directions: when to take Témesta?

It has been said: the drug Témesta® is an anxiolytic. Its main indications are therefore:

  • The Generalized Anxiety Disorder (GAD) which corresponds, according to the Haute Autorité de Santé, to a ” excessive and inappropriate worry, persistent (at least several months) and not limited to particular situations “,
  • Anxiety when associated with a neurosis – in case of phobia, hypochondria or hysteria,
  • Anxiety attacks,
  • Prevention and treatment of delirium tremens,
  • Alcohol withdrawal.
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Témesta: instructions for use. Of course, it is essential to strictly adhere to the dosage recommended by the doctor. As a guide, the reference dose for adults is 2 to 4 mg of Temesta® per day. This medication is prohibited in children under 6 years of age.

The duration of treatment can never exceed 12 weeks. In the event of anxiety associated with a situation or a pathology, it is generally between 4 and 12 weeks; in the event of alcohol withdrawal, between 3 and 6 weeks; in the event of an anxiety attack, it is only a few days.

To know. While taking Temesta®, it is recommended not to drink alcohol to avoid worsening the side effects (drowsiness, in particular).

Témesta: precautions for use

Attention ! The drug Temesta® is contraindicated in people with severe hepatic impairment, severe respiratory failure, sleep apnea syndrome and / or myasthenia gravis.

Can Temesta be taken during pregnancy? The drug Témesta® is contraindicated during pregnancy: there is indeed an increased risk of cleft lip and palate (or “harelip”) in the unborn baby, but also of cardiac, respiratory and / or muscular abnormalities. .

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The Reference Center on Teratogenic Agents (CRAT) recommends favoring other anxiolytic drugs during pregnancy ” at minimum effective dosage and for the shortest possible time “: oxazepam or hydroxyzine, for example.

What about during breastfeeding? During breast-feeding, the only anxiolytic drug tolerated is oxazepam (Séresta®), only under strict medical supervision. Other anxiolytics can indeed pass into breast milk and be responsible for serious side effects in children.

What are the side effects of Temesta?

To know. Like most benzodiazepines, Temesta® can be responsible for dependence, especially in people already dependent on other drugs or alcohol.

Thus, suddenly stopping treatment with Temesta® can lead to a withdrawal syndrome characterized by anxiety, restlessness, irritability, insomnia, headaches, muscle pain, tremors. and / or hallucinations. It is therefore essential to stop treatment gradually, ” with decreasing dosage over several weeks “specifies the High Authority of Health (HAS).

The drug Témesta® can be the cause of side effects which affect between 1% and 10% of patients:

  • A decrease in vigilance, even drowsiness, especially in elderly patients,
  • Confusion, difficulty coordinating movements,
  • Muscle weakness
  • Abnormal fatigue,
  • Libido disorders.
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More rarely, we can observe memory problems, irritability or even aggressiveness, headaches, dizziness, skin rashes, hypotension with discomfort …

Sources :

Vidal Encyclopedia

High Authority of Health (HAS)

Public drug database

Reference Center on Teratogenic Agents (CRAT)

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