Xatral (alfuzosin): what to know about this drug for benign prostatic hyperplasia

What is the drug Xatral?

Xatral® is a drug that belongs to the alpha blocker family. Prescribed for men only, it acts on the bladder, urethra (that is to say: the conduit through which urine flows) and the prostate (the male gland which is located under the bladder) , and in particular regulates the contraction of the urinary tract.

Xatral: how does it work? The active principle of the drug Xatral® is alfuzosin: this molecule decreases the pressure in the urethra, which facilitates the passage of urine and improves urinary symptoms without negative impact on sexual functions.

In pharmacies, the drug Xatral® exists in 2 forms:

  • Xatral 2.5 mg®: box of 30 white tablets,
  • Xatral LP 10 mg®: box of 30 yellow and white prolonged-release tablets.

To know. The drug Xatral® can only be obtained with a medical prescription: it is not over-the-counter in pharmacies. It is reimbursed up to 30% by the Health Insurance. Its generic is Alfuzosine®. It has been marketed since the 1990s by the Sanofi-Aventis France laboratory.

Indications: when to take Xatral?

The main indication of the drug Xatral® is hyperplasia or benign prostatic hyperplasia (BPH): this frequent pathology (urologists estimate that 80% of men will be affected during their life) corresponds to an abnormal swelling of the cells. that make up the prostate: these then compress the urethral canal, causing mainly urinary symptoms – inconvenience to urinate, more frequent urge to urinate …

According to the French National Authority for Health (HAS), Xatral® is a ” first-line symptomatic treatment “against BPH.

And also. Since May 2011, alpha-blocker drugs (including Xatral®) have also been reimbursed by Health Insurance as part of the treatment of urinary disorders in men suffering from multiple sclerosis.

Xatral: instructions for use. Of course, it is important to adhere to the dosage indicated by the doctor. As a guide, the reference dose for adult men is 1 tablet of Xatral 2.5 mg® 3 times a day, or 1 tablet of Xatral LP 10 mg® in the evening.

Attention : In order for the medicine to be effective, it is recommended not to chew, chew, crush or powder Xatral® tablets. The tablets are to be taken preferably after meals.

Xatral: precautions for use

Attention ! The drug Xatral® is strictly contraindicated in the event of allergy to the active principle (alfuzosin), in the event of orthostatic hypotension (this drop in blood pressure occurs when one stands up and is often accompanied by discomfort and / or dizziness), in severe liver or kidney disease (including: renal failure or severe hepatitis) and in treatment for hepatitis C (eg ombitasvir or paritaprevir).

It is best to avoid taking Xatral® when you are already taking treatment for high blood pressure (for example: doxazosin, prazosin or urapidil), against HIV (AIDS), against certain fungal diseases (itraconazole, posaconazole) , against depression (nefazodone) or against certain bacterial diseases (clarithromycin, erythromycin, telithromycin). In addition, care is needed in patients with cerebral circulatory disorders, heart failure and / or cardiac arrhythmias.

And also. The drug Xatral® should not be used in children before the age of 16. It is not intended for women.

What are the side effects of Xatral?

To know. At the start of treatment, postural hypotension may be observed within hours of taking the drug: this is a feeling of malaise, possibly accompanied by dizziness, dizziness, fatigue and / or sweating. , which occurs when you (re) stand up. Usually mild, this side effect should still be reported to the doctor. It is therefore preferable to avoid driving at the start of treatment.

The drug Xatral® can be at the origin of “frequent” side effects which affect between 1% and 10% of patients:

  • Nausea,
  • Abdominal pain,
  • Headache,
  • Discomfort (orthostatic hypotension) …

Attention : Rarely, Xatral® can be responsible for priapism: this prolonged and painful erection which persists / which appears in the absence of sexual stimuli requires urgent medical consultation!

Sources :

Public drug database

Vidal Encyclopedia

High Authority of Health (HAS)

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